Malat1 endothelial

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August undefined, 2024

WebObjectives: Maturation of dendritic cells (DCs) contributes to atherosclerosis (AS) development. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) that is involved in tumorigenesis. This study was … Web12 apr. 2024 · A CARPID-derived protein interactome study of MALAT1 (W. Yi et al., 2024) identified guanine nucleotide-binding protein G(S) protein, involved in cell proliferation ... orchestrated by a range of secreted factors and signaling pathways and can involve participation of non-endothelial cells, such as progenitors or cancer stem cells ...

MALAT1: An Epigenetic Regulator of Inflammation in …

WebEndothelial-specific overexpression of MYC was sufficient to induce type H bone endothelial cells, ... In this study, the effect of the lncRNA … Web6 mrt. 2024 · Abstract. Stroke is one of the leading causes of death and long-term disability around the world. Angiogenesis is supposed to protect brain microvascular endothelial cells (BMECs) from oxidative and ischemic stress. Previous studies indicated that interaction between metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and miR … tieng shoe

Sci-Hub MALAT1/miR-15b-5p/MAPK1 mediates endothelial …

WebLong non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells. To examine whether the long non-coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) is altered in the endothelial … Web28 nov. 2024 · MALAT1 deficiency was previously shown to reduce endothelial cell proliferation, 6 and this might also have contributed to augmented atherosclerosis, particularly in the low-flow regions of the vascular tree, where endothelial cell proliferation is an important protective repair mechanism. 26 On the other hand, one may speculate that … Web3 jun. 2024 · An early study identified MALAT1 upregulation in endothelial cells subjected to high glucose treatment . MALAT1 was also found to play an important role in regulating insulin sensitivity by regulating NRF2 activity and suppressing JNK signaling with concomitant insulin-induced phosphorylation of Akt [ 146 ]. the marchesiello team

MALAT1: A regulator of inflammatory cytokines in diabetic complications ...

(PDF) Knockdown of lncRNA MALAT1 Alleviates LPS-Induced …

WebPrevious results suggested that Sirt6 mediated transcriptional suppression of MALAT1 is a key mechanism for EndMT in a model of ECs aging, 26 future research should focus on the role of Sirt6 and target ... Qin W, Zhang L, Li Z, et al. SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal ... Web3 jan. 2024 · Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA contributing to protect the blood–brain barrier (BBB) after stroke. We searched for small molecules that may up-regulate MALAT1 and focused on polydatin (PD), a natural product, as a possible candidate. PD enhanced MALAT1 gene expression in … tieng thaiWeb18 jun. 2024 · MALAT1 and MIAT lncRNAs are associated with the angiogenesis process. MALAT1 induces hypoxia-driven angiogenesis via the overexpression of angiogenic genes. Down regulation of MIAT1 could inhibit the proliferation of … the marches grants

"Web5 feb. 2024 · Long noncoding RNA MALAT1 promotes high glucose-induced inflammation and apoptosis of vascular endothelial cells by regulating miR-361-3p/SOCS3 axis. Kai Huang, Xuxia Yu, Yushan Yu, Lu Zhang, Y. Cen, Jinguo Chu Biology, Medicine International journal of clinical and experimental pathology 2024 TLDR " - Malat1 endothelial

Malat1 endothelial

MALAT1 promotes angiogenesis of breast cancer

Webpaper showed that MALAT1 controls a phenotypic switch in endothelial cell and regulates its function and vessel growth [18]. It has also been demonstrated that MALAT1 plays a pathogenic role in endothelial cell dysfunction in diabetes mellitus [19]. However, whether MALAT1 is in-volved in regulating EPC function in T2DM remains un-known. Web6 jan. 2024 · Knocking down of MALAT1 and miR-181a-5p could both improve the outcome in ALI/ARDS rats. MALAT1 antagonism or miR-181a-5p could both be potential ... Manavski Y, Doddaballapur A, Zörnig M, Braun T, John D, Ponomareva Y, Chen W, Uchida S, et al. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth ...

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Web30 okt. 2014 · Their increases have a critical role in endothelial cell migration and tube formation, thereby causing retinal vessel impairment. 11 Here we investigated the effect of MALAT1 knockdown on VEGF ... Web25 apr. 2024 · Here, we first determined the expression level of MALAT1 in human retinal microvascular endothelial cells (HRECs) cultured in high glucose (HG) and subsequently analyzed the expressions of...

Web6 apr. 2024 · Besides, Malat1 is involved in pathogenesis of various vascular diseases by regulating endothelial, smooth muscle cell and hematopoietic stem cell functions [22,23,24]. Cremer et al . found that suppressed Malat1 level augments atherosclerotic lesion formation in mice and that Malat1 inhibits Lin − Sca1 + c-kit + (LSK) progenitor cell proliferation [ 24 ].

Web7 feb. 2024 · Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is an important member of the lncRNA family; it is approximately 8,700 nt in length and is localized to human chromosome 11q13.1. It belongs to intergenic lncRNA and is one of the most widely studied lncRNAs ( 4 ). Web13 okt. 2024 · The goal of this study is to investigate the role of LncRNA MALAT1 in the development of diabetic retinopathy, specifically in the regulation oxidative stress, via Keap1-Nrf2 interactions. Using human retinal endothelial cells (HRECs), we investigated the effect of high glucose on LncRNA MALAT1 expression and the regulation of LncRNA …

WebMALAT1 is associated with vascular endothelial cell homeostasis , and reduced MALAT1 expression may impede vascular repair after SARS-CoV-2 infection. MT-CO1 (ENSG00000198804), as a second parameter, was downregulated in vascular …

WebMALAT1, originally identified in pulmonary adenocarcinoma, is among the most abundant lncRNA in the nervous system. It is described as heavily expressed in different types of neurons in mice (Bernard et al., 2010 ). MALAT1 is found in nuclear foci and appears to regulate synapse formation ( Bernard et al., 2010 ). the marches medical centreWeb21 mei 2024 · MALAT1 and miR-205-5p were both significantly upregulated in the serum of CIS patients and HBMECs under OGD/R, and the tube formation of HBMECs was damaged after OGD/R treatment. Silencing miR-205-5p remarkably promoted HBMEC … the marches local enterprise partnership areaWebMALAT1 is associated with vascular endothelial cell homeostasis , and reduced MALAT1 expression may impede vascular repair after SARS-CoV-2 infection. MT-CO1 (ENSG00000198804), as a second parameter, was downregulated in vascular endothelial cells after SARS-CoV-2 infection in this rule. tieng thongdy channelWeb29 jul. 2024 · The lncRNA MALAT1 protects the endothelium against ox-LDL-induced dysfunction via upregulating the expression of the miR-22-3p target genes CXCR2 and AKT. FEBS Lett. 2015;589: 3189 – 3196. , , [Web of Science ®], [Google Scholar] Zeng R, Zhang R, Song X, et al. the marches lanarkWeb13 jan. 2024 · MALAT1 knockdown inhibited HYP-induced injury and autophagy by suppressing HIF-1α expression. First, the role of MALAT1 in HYP-induced VEC injury was investigated. As shown in Fig. 1 a, the level of HIF-1α in HUVECs was increased in a … the marches lineWeb10 sep. 2024 · Background . Endothelial dysfunction commonly occurs in obese children and adolescents, leading to an increased risk of cardiovascular diseases. Exercise has significant protective effects against endothelial dysfunction through regulating some noncoding RNAs. This study aimed to investigate the relationship of long noncoding RNA … tieng thet 5Web5 feb. 2024 · Recently, MALAT1 was identified as a pyroptosis-related long noncoding RNA (lncRNA). Here, we investigated the potential role and underlying mechanism of lncRNA MALAT1 in endothelial cells pyroptosis. We first established an endothelial cell … tieng thongdy