Fatty acid synthase uniprot
WebMay 9, 2014 · Human fatty acid synthase (hFAS) is a complex, multifunctional enzyme that is solely responsible for the de novo synthesis of long chain fatty acids. hFAS is highly expressed in a number of cancers, with low expression observed in most normal tissues. WebApr 9, 2024 · The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the …
Fatty acid synthase uniprot
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Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene. Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one … WebUniProt P95029 · P95029_MYCTU Protein Probable fatty acid synthase Fas (Fatty acid synthetase) Gene fas Status UniProtKB unreviewed (TrEMBL) Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Amino acids 3069 Protein existence Evidence at protein level Annotation score 2/5 Entry Feature viewer Publications External links …
WebOxaloacetate is an intermediate of the citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalyzed by citrate synthase. It is also involved in gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. Oxaloacetate is also a potent inhibitor of complex II . Gluconeogenesis [ edit] WebDec 2, 2013 · UniProt ID Recommended name P21731 thromboxane A2 receptor P24557 thromboxane A synthase 1 (platelet) P35610 sterol O-acyltransferase 1 O14975 solute carrier family 27 (fatty acid transporter), member 2 P35354 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) P23219 prostaglandin …
WebMar 21, 2024 · FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with FASN include Non-Alcoholic Fatty Liver Disease and Fatty Liver Disease.Among its … WebMar 9, 2007 · In the multifunctional fungal fatty acid synthase (FAS), the acyl carrier protein (ACP) domain shuttles reaction intermediates covalently attached to its prosthetic phosphopantetheine group between the different enzymatic centers of the reaction cycle. Here, we report the structure of the Saccharomyces cerevisiae FAS determined at 3 ...
WebMay 15, 2009 · The human fatty acid synthase (FAS) is a key enzyme in the metabolism of fatty acids and a target for antineoplastic and antiobesity drug development. Due to its …
WebFatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa … chrysler dealership baltimore mdWebAminolevulinic acid dehydratase ( porphobilinogen synthase, or ALA dehydratase, or aminolevulinate dehydratase) is an enzyme ( EC 4.2.1.24) that in humans is encoded by the ALAD gene. descargar windows rar gratisWebFatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of ... descargar windows qqWebDec 14, 2015 · Fatty acids are the major components of these highly important lipids and fatty acid synthase (FASN) is the lone lipogenic enzyme in humans able to synthesize these all important fatty acids de novo. Herein, we describe the potential therapeutic implications of inhibiting FASN in cancer patients. chrysler dealership baltimoreWebKey features and details Rabbit polyclonal to Fatty Acid Synthase Suitable for: WB, IHC (PFA fixed), ICC Knockout validated Reacts with: Mouse, Rat, Human Isotype: IgG Get better batch-to-batch reproducibility with a recombinant antibody Anti-Fatty Acid Synthase antibody [EPR7466] (ab128870) descargar windows server 2019 mediafireWebJul 31, 2008 · Mammalian fatty acid synthase is a large multienzyme that catalyzes all steps of fatty acid synthesis. We have determined its crystal structure at 3.2 angstrom resolution covering five catalytic domains, whereas the flexibly tethered terminal acyl carrier protein and thioesterase domains remain unresolved ... Macromolecules descargar windows sidebar para windows 10WebActs as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 ( PubMed: 31618756 ). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation ... descargar win mu