WebMay 24, 2010 · Background Connective Tissue Growth Factor (CTGF/CCN2), a known matrix-associated protein, is required for the lactogenic differentiation of mouse mammary epithelial cells. An HC11 mammary epithelial cell line expressing CTGF/CCN2 was constructed to dissect the cellular responses to CTGF/CCN2 that contribute to this … WebConnective tissue growth factor (CTGF) is a cysteine-rich peptide synthesized and secreted by fibroblastic cells after activation with transforming growth factor beta (TGF-beta) that acts as a ...
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WebJun 1, 2024 · Connective tissue growth factor (CTGF), also known as CCN2, is a member of the CCN family of proteins and is thought to be involved in extracellular matrix production, desmoplasia, tumor cell proliferation, adhesion, migration, angiogenesis, and … WebCTGF has multiple functions including promotion proliferation and differentiation of chondrocytes; mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells, and enhances fibroblast growth factor-induced DNA synthesis.
WebConnective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, … WebFeb 20, 2006 · 1.. IntroductionCCN family protein 2/connective tissue growth factor (CCN2/CTGF) regulates cell adhesion, migration, proliferation, survival, differentiation, and gene expression in a number of cell types isolated from tissues, including chondrocytes [1].CCN2/CTGF is a member of the CCN family (Cyr61, CTGF, Nov); it is strongly …
WebJun 1, 2024 · Located on chromosome band 6q23.1, the CTGF gene contains five exons and four introns, with each exon encoding a distinct module in the protein (Figure 1) [3].In most cases, de novo protein synthesis is not required for CTGF expression because it is an early-response gene and is regulated at the transcriptional level [11., 12., 13.Exquisitely … WebExperiments using recombinant CTGF and neutralizing antibodies targeting CTGF have suggested that CTGF mediates at least some of the effects of TGF-β on fibroblast proliferation, adhesion, and ECM production, including collagen and fibronectin ( Crean et al., 2002; Weston et al., 2003 ). Moreover, an expression vector encoding CTGF …
WebOverexpression of CTGF enhances resistance to 5-FU-promoting cell death. To examine the potential role of CTGF on the regulation of chemoresistance to 5-FU, we first confirmed that the pCDNA3.1-CTGF vector and CTGF small interfering RNA (CTGF-siRNA) were overexpressing and interfering with the protein and mRNA of CTGF in HT-29 and SW620 …
WebJan 26, 2006 · 1 Introduction. CCN family protein 2/connective tissue growth factor (CCN2/CTGF) regulates cell adhesion, migration, proliferation, survival, differentiation, and gene expression in a number of cell types isolated from tissues, including chondrocytes [].CCN2/CTGF is a member of the CCN family (Cyr61, CTGF, Nov); it is strongly … camping rolandseckWebJul 12, 2014 · Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth … camping rock springs wyWebNov 4, 2016 · CTGF is a matricellular, multifunctional protein that can influence the activity of multiple major signaling pathways, affecting cell adhesion, migration, proliferation, and differentiation. CTGF expression increases after central nervous system (CNS) trauma in rodents, but its function after spinal cord injury has not been elucidated ( 7 – 9 ). fischer comfort cruiser crownWebCTGF is among the most highly expressed genes in the human TM, and it is tempting to speculate that the function of CTGF signaling in the TM involves the remodeling of … fischer comfortWebOct 29, 2024 · Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such … camping roland zooverWebThe extracellular matrix components involved in CTGF-regulated adhesion were determined. Recombinant CTGF was added to cells or coinoculated with gastric cancer cells into mice to evaluate its therapeutic potential. Results: CTGF overexpression and treatment with the recombinant protein significantly inhibited cell adhesion. In vivo peritoneal ... camping roland duitslandWebMay 24, 2010 · Background Connective Tissue Growth Factor (CTGF/CCN2), a known matrix-associated protein, is required for the lactogenic differentiation of mouse … camping rolde de weyert