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Cd63 protein function

Web脑梗死又称缺血性卒中,是指各种原因所致脑部血液供应障碍,导致脑组织缺血、缺氧,出现相应神经功能缺损[1]。动脉硬化是本 ... WebNov 2, 2024 · The NanoDeep method converts protein spatial distribution information into a DNA sequencing readout (Fig. 1).We designed a DNA nanoassembly, which we named a NanoComb, composed of four single ...

A cell-based assay for CD63-containing extracellular vesicles

WebMar 21, 2024 · Go to Variation Viewer for CD63 variants; Summary. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the … WebJan 23, 2007 · Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and … inductive loop https://tierralab.org

Protein structure - CD63 - The Human Protein Atlas

In cell biology, CD63 is often used as a marker for multivesicular bodies, which in some cells are enriched with CD63, as well as for extracellular vesicles released from either the multivesicular body or the plasma membrane. Interactions. CD63 has been shown to interact with CD117 and CD82. See also. Cluster of … See more CD63 antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of intracellular vesicles, although cell surface expression may be induced. See more The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of … See more Initially, deletion and point mutants were used to investigate the role of the C-terminus, which contains a putative lysosomal-targeting/internalisation motif (GYEVM). C-terminal mutants showed increased surface expression and decreased … See more • Mal G (2012). Investigation of cellular functions of tetraspanin CD63. Germany: LAP LAMBERT Academic Publishing (LAP), GmbH & Co. ISBN 978-3-659-18758-2 See more CD63 is a good marker for flow cytometric quantification of in vitro activated basophils for diagnosis of IgE-mediated allergy. The test is commonly designated as basophil … See more CD63 has been shown to interact with CD117 and CD82. See more • Cluster of differentiation See more WebCD63 was first detected as a marker of platelet activation, which is increased on the surface of platelets after granule release (Chapter 18 ). It was subsequently found to be a 53-kDa lysosomal membrane protein with four transmembrane domains and three putative N-glycosylation sites. 166 CD63 has been found to be associated with integrins 167 ... WebMar 29, 2024 · It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been … inductive logic programming ilp

CD63 CD63 molecule [Homo sapiens (human)] - Gene - NCBI

Category:The Exosome‐Associated Tetraspanin CD63 Contributes to the …

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Cd63 protein function

Trafficking and function of the tetraspanin CD63 - ScienceDirect

WebMay 15, 2009 · At the cell surface, tetraspanins form networks with a wide diversity of proteins called tetraspanin-enriched microdomains (TEMs). CD63 was the first … WebHowever, a fundamental challenge in the engineering of exosomes is the design of biocompatible molecular scaffolds on their surface to enable cell targeting and …

Cd63 protein function

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WebProtein concentration was determined with the DC protein assay kit (Bio-Rad, Hercules, CA, USA). ... In this report, we demonstrate a novel function of the TIMP-1–CD63 … WebDec 5, 2003 · The tetraspanin CD63 is a highly glycosylated protein that is widely but not ubiquitously expressed ().Although CD63 is typically regarded as a resident of late endosomes and lysosomes, it is present also in secretory vesicles as well as at the plasma membrane, and it cycles among these compartments (2, 5–7).This tetraspanin has …

WebMar 6, 2024 · Lysosomal associated membrane protein 3; CD 63; CD63; CD63 antigen; CD63 antigen (melanoma 1 antigen) CD63 antigen melanoma 1 antigen; CD63 molecule; CD63_HUMAN; gp55; Granulophysin; LAMP 3; LAMP-3; LAMP3; ... Function. This antigen is associated with early stages of melanoma tumor progression. May play a role in … WebCD63. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC.

WebMay 31, 2014 · The tetraspanin CD63 is a highly N-glycosylated protein that is known to regulate cancer malignancy. However, the contribution of glycosylation of CD63 to cancer malignancy remains unclear. Previously, we reported that ribophorin II (RPN2), which is part of an N-oligosaccharyle transferase complex, is responsible for drug resistance in breast … WebAug 27, 2024 · The mechanisms involved in the regulation of the pleiotropic functions of TIMP-1 are still poorly understood. Thus, this review aimed to present literature data that show its ability to form a membrane complex with CD63 and β1-integrin, and point to N-glycosylation as a potential regulatory mechanism of the functions exerted by TIMP-1. …

WebFeb 24, 2024 · Many exosome-specific or -selective proteins are displayed on exosome membranes, including several tetraspanin proteins (e.g. CD81, CD82, CD37, and CD63) and proteins involved in cell adhesion and signaling, cytoskeletal structures, lipid rafts, and membrane trafficking. 16 These include two members of the endosomal sorting complex …

WebCD9, CD63, CD81, and CD82 are glycoproteins of unknown function which belong to the tetraspan superfamily. These molecules have short cytoplasmic sequences, four … inductive logic programming markov gamesWebCD9, CD63, CD81, and CD82 are glycoproteins of unknown function which belong to the tetraspan superfamily. These molecules have short cytoplasmic sequences, four transmembrane domains and two unequal extracellular regions. Here, we show that these molecules are associated with each other on cell sur … inductive loop cableWebApr 6, 2024 · Tetraspanins are membrane-spanning proteins with a conserved structure that function primarily as membrane protein organizers. ... More recently, CD63 was shown to stabilize β-catenin … inductive loop traffic counterWebCD9 and CD63 belong to a tetramembrane-spanning glycoprotein family called tetraspanin, and are involved in a wide variety of cellular processes, but the structure-function relationship of this family of proteins has yet to be clarified. CD9 associates with diphtheria toxin receptor (DTR), which is … logback stdout consoleWebFeb 15, 2024 · Typically, exosomes are highly enriched in proteins with various functions, such as tetraspanins (CD9, CD63, CD81, CD82), which take part in cell penetration, invasion, and fusion events; heat shock proteins (HSP70, HSP90), as part of the stress response that are involved in antigen binding and presentation; MVB formation proteins … inductive loop sawcutWeb6 hours ago · In our study, we characterized the role of MVBs by comparing them to largely well-characterized ISGs in beta-cells. We compared the density, localization, and exocytosis of MVBs with ISGs in beta-cells. For this, we developed a novel probe where we exploit the efficiency of tetraspanins CD63 and CD151 to label the MVBs in beta-cells. inductively cogentWebThe Human Disease Blood Atlas contains information on the protein levels in blood in patients with different diseases, as well as, the panels of proteins associated with the diseases according to AI-based prediction models. Read more. Immunei. The Immune cell section contains single cell type mRNA expression data for human protein-coding genes ... inductive loop symbol